Artículos Científicos
Recent Submissions
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Reporte de caso clínico Primer diagnóstico de Rhodococcus equi confirmado, laboratorialmente, en un potrillo de Costa Rica
(Universidad Nacional, Costa Rica, 2020-03-09)Neumonía por Rhodococcus equi es importante causa de morbilidad y mortalidad en potrillos de todo el mundo. La prevalencia y/o virulencia de la bacteria es, aparentemente, baja en Costa Rica, pues nunca han sido reportados ... -
Chromobacterium violaceum infection in a free ranging howler monkey in Costa Rica
(Wildlife Disease Association, 2010)Chromobacterium violaceum is a gram-negative saprobe bacterium that is a rare opportunistic pathogen in mammals. There are numerous reports in humans including fatalities, but no record exists in free-ranging nonhuman ... -
Brucella abortus ornithine lipids are dispensable outer membrane components devoid of a marked pathogen-associated molecular pattern
(PLoS One, 2011-01-07)The brucellae are a-Proteobacteria facultative intracellular parasites that cause an important zoonosis. These bacteria escape early detection by innate immunity, an ability associated to the absence of marked pathogen-associated ... -
Brucella ceti and brucellosis in cetaceans
(Frontiers in cellular and infection microbiology, 2012-02-06)Since the first case of brucellosis detected in a dolphin aborted fetus, an increasing number of Brucella ceti isolates has been reported in members of the two suborders of cetaceans: Mysticeti and Odontoceti. Serological ... -
Bacterial counts in spleen
(Bio-protocol, 2013-11-05)Bacterial loads can be determined as colony forming units (CFU) at any point of the infection by culturing spleen homogenates on agar plates. This is a reliable method for comparing the kinetics of infection in various ... -
Estandarización de un protocolo de caracterización molecular para la identificación de especie de cepas terrestres de bacterias del género Brucella
(Ediciones Unisalle, 2011-10-03)La brucelosis es la enfermedad zoonótica más extendida en el mundo que afecta diversos animales, incluyendo especies domésticas y de vida silvestre. Es causada por una bacteria perteneciente al género Brucella, el cual ... -
Multidrug-Resistant CTX-M and CMY-2 producing Escherichia coli Isolated from healthy household dogs from the great metropolitan area, Costa Rica
(Mary Ann Liebert, Inc., 2020)Objective:This study aimed to determine the prevalence of fecal carriage of antibiotic-resistantEscherichia coliof healthy household dogs with an emphasis on extended-spectrumb-lactamases (ESBL), AmpC-typeb-lactamases ... -
In vivo proteolytic degradation of the Escherichia coli acyltransferase HlyC
(The American Society for Biochemistry and Molecular Biology, 2001-05-18)Escherichia coli hemolysin (HlyA) is the prototype toxin of a major family of exoproteins produced by Gram-negative bacteria known as “repeats in toxins.” Only fatty acid-acylated HlyA molecules at residues Lys564 and ... -
The two-component system BvrR BvrS essential for Brucella abortus virulence regulates the expression of outer membrane proteins with counterparts in members of the Rhizobiaceae
(Proceedings of the National Academy of Sciences, 2002-09-17)The Brucella BvrR/BvrS two-component regulatory system is homologous to the ChvI/ChvG systems of Sinorhizobium meliloti and Agrobacterium tumefaciens necessary for endosymbiosis and pathogenicity in plants. BvrR/BvrS ... -
GTPases of the Rho subfamily are required for Brucella abortus internalization in nonprofessional phagocytes
(The American Society for Biochemistry and Molecular Biology, Inc., 2001-11-30)Members of the genus Brucella are intracellular -Proteobacteria responsible for brucellosis, a chronic disease of humans and animals. Little is known about Brucella virulence mechanisms, but the abilities of these ... -
Activation of Rho and Rab GTPases dissociates Brucella abortus internalization from intracellular trafficking
(Blackwell Science, 2002-10-04)Brucella abortus is an intracellular pathogen that relies on unconventional virulence factors to infect hosts. In non-professional phagocytes, Rho GTPasesactivation by the Escherichia coli cytotoxic necrotiz ing factor ... -
Regulation of Brucella virulence by the two-component system BvrR/BvrS
(Elsevier B.V., 2002-12-20)The Brucella BvrR/BvrS two-component regulatory system is highly similar to the regulatory and sensory proteins of Sinorhizobium and Agrobacterium necessary for endosymbiosis and pathogenicity in plants, and very similar ... -
R-Ras Glucosylation and transient RhoA activation determine the cytopathic effect produced by Toxin B variants from Toxin A-negative strains of clostridium difficile
(American Society for Biochemistry and Molecular Biology, 2003-03-07)Clostridium difficile induces antibiotic-associated diarrhea through the production of toxin A and toxin B; the former toxin has been assumed to be responsible for the symptoms of the disease. Several toxin A-negative ... -
Serological detection of viral infections in captive wild cats from Costa Rica
(Veterinary Medicine International, 2011-02-08)Serum samples from a total of 44 wildcats, 28 margays (Leopardus wiedii), 10 ocelots (Leopardus pardalis), four jaguaroundis (Herpailurus yaguaroundi), one oncilla (Leopardus tigrina), and one jaguar (Panthera onca) were ... -
Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infection
(PLOS ONE, 2007-07-18)Background. To unravel the strategy by which Brucella abortus establishes chronic infections, we explored its early interaction with innate immunity. Methodology/Principal Findings. Brucella did not induce proinflammatory ... -
BvrR/BvrS-controlled outer membrane proteins Omp3a and Omp3b are not essential for Brucella abortus virulence
(American Society for Microbiology, 2007-07-30)The Brucella abortus two-component regulatory system BvrR/BvrS controls the expression of outer membrane proteins (Omp) Omp3a (Omp25) and Omp3b (Omp22). Disruption of bvrS or bvrR generates avirulent mutants with altered ... -
Neurobrucellosis in stranded dolphins, Costa Rica
(Universidad Nacional, Costa Rica, 2008-09)Ten striped dolphins, Stenella coeruleoalba, stranded along the Costa Rican Pacifi c coast, had meningoencephalitis and antibodies against Brucella spp. Brucella ceti was isolated from cerebrospinal fl uid of 6 dolphins ... -
Intracellular adaptation of Brucella abortus
(Universidad Nacional, Costa Rica, 2009-03)Macrophages were infected with virulent B. abortus strain 2308 or attenuated strain 19. Intracellular bacteria were recovered at different times after infection and their proteomes compared. The virulent strain initially ... -
Serological diagnosis of brucella infections in odontocetes
(American Society for Microbiology, 2009-04-15)Brucella ceti causes disease in Odontoceti. The absence of control serum collections and the diversity of cetaceans have hampered the standardization of serological tests for the diagnosis of cetacean brucellosis. Without ... -
The role of neutrophils in Brucellosis
(American Society for Microbiology, 2020-10-14)Brucellosis is a bacterial disease of domestic animals and humans. The pathogenic ability of Brucella organisms relies on their stealthy strategy and their capacity to replicate within host cells and to induce long-lasting ...
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