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Now showing items 1-20 of 29

    • Activation of Rho and Rab GTPases dissociates Brucella abortus internalization from intracellular trafficking 

      Chaves-Olarte, Esteban; Guzman-Verri, Caterina; Méresse, Stephane; Desjardins, Michel; Pizarro-Cerdá, Javier; Badilla, Jenny; Gorvel, Jean-Pierre; Moreno, Edgardo (Blackwell Science, 2002-10-04)
      Brucella abortus is an intracellular pathogen that relies on unconventional virulence factors to infect hosts. In non-professional phagocytes, Rho GTPasesactivation by the Escherichia coli cytotoxic necrotiz ing factor ...

    • Brucella abortus senses the intracellular environment through the BvrR/Bvrs two-component system, which allows B. abortus to adapt to its replicative nich 

      Altamirano-Silva, Pamela; Meza-Torres, Jazmín; Castillo-Zeledón, Amanda; Ruiz-Villalobos, Nazareth; Zúñiga Pereira, Ana Mariel; Chacón-Díaz, Carlos; Moreno, Edgardo; Guzman-Verri, Caterina; Chaves-Olarte, Esteban (American Society for Microbiology., 2018-01-16)
      Brucella abortus is a facultative extracellular-intracellular pathogen belonging to a group of Alphaproteobacteria that establishes close interactions with animal cells. This bacterium enters host cells in a membrane-bound ...

    • Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infection 

      BARQUERO-CALVO, ELIAS; Chaves-Olarte, Esteban; Weiss, David; Guzman-Verri, Caterina; Chacón-Díaz, Carlos; Rucavado, Alexandra; Moriyon, Ignacio; Moreno, Edgardo (PLOS ONE, 2007-07-18)
      Background. To unravel the strategy by which Brucella abortus establishes chronic infections, we explored its early interaction with innate immunity. Methodology/Principal Findings. Brucella did not induce proinflammatory ...

    • Brucella genetic variability in wildlife marine mammals populations relates to host preference and ocean distribution 

      Suárez-Esquivel, Marcela; Baker, Kate; Ruiz-Villalobos, Nazareth; Hernandez-Mora, Gabriela; BARQUERO-CALVO, ELIAS; González-Barrientos, Rocío; Castillo-Zeledón, Amanda; Jiménez-Rojas, César; Chacón-Díaz, Carlos; Cloeckaert, Axel; Chaves-Olarte, Esteban; Thomson, Nicholas; Moreno, Edgardo; Guzman-Verri, Caterina (Oxford University Press on behalf of the Society for Molecular Biology and Evolution, 2017-07-20)
      Intracellular bacterial pathogens probably arose when their ancestor adapted from a free-living environment to an intracellular one, leading to clonal bacteria with smaller genomes and less sources of genetic plasticity. ...

    • Brucellosis in mammals of Costa Rica: an epidemiological survey 

      Hernández-Mora, Gabriela; Bonilla-Montoya, Roberto; Barrantes-Granados, Osvaldo; Esquivel-Suárez, Andrea; Montero-Caballero, Danilo; Fallas-Monge, Zeanne; Palacios Alfaro, Jose David; Baldi, Mario; Campos, Elena; Chanto, Grettel; BARQUERO-CALVO, ELIAS; Chacón-Díaz, Carlos; Chaves-Olarte, Esteban; Guzman-Verri, Caterina; Romero-Zúñiga, Juan José; Moreno, Edgardo (PLOS ONE, 2017-08-09)
      La brucelosis ha sido una enfermedad endémica del ganado y los seres humanos en Costa Rica desde principios del siglo XX. Sin embargo, no se ha reportado brucelosis en ovejas, cabras, cerdos, búfalos de agua, caballos y ...

    • BvrR/BvrS-controlled outer membrane proteins Omp3a and Omp3b are not essential for Brucella abortus virulence 

      Manterola, Lorea; Guzman-Verri, Caterina; Chaves-Olarte, Esteban; BARQUERO-CALVO, ELIAS; de Miguel, María-Jesús; Moriyon, Ignacio; Grillo, María-Jesús; López-Goñi, Ignacio; Moreno, Edgardo (American Society for Microbiology, 2007-07-30)
      The Brucella abortus two-component regulatory system BvrR/BvrS controls the expression of outer membrane proteins (Omp) Omp3a (Omp25) and Omp3b (Omp22). Disruption of bvrS or bvrR generates avirulent mutants with altered ...

    • Combined electrokinetic manipulations of pathogenic bacterial samples in low-cost fabricated dielectrophoretic devices 

      Martinez-Brenes, Alejandro; Torres-Castro, Karina; Marín-Benavides, Richard; Acuña-Umaña, Katherine; Espinoza Araya, Christopher; Ramírez-Carranza, Raquel; González-Espinoza, Gabriela; Rojas-Campos, Norman; Guzman-Verri, Caterina; Sáenz-Arce, Giovanni; Lesser-Rojas, Leonardo (AIP Advances, 2019-11-13)
      A low-cost fabrication method of microfluidic devices with micrometer-sized constrictions used for electrodeless dielectrophoresis (eDEP) is demonstrated here. A structure on a commercial printed circuit board (PCB) ...

    • Distribución del Pequeño Escarabajo de la Colmena, Aethina tumida, en abejas africanizadas (Apis mellifera) en diferentes zonas apícolas de Costa Rica 

      Arguedas Mora, Martha; Soto González, Juan Francisco; Ramírez Montero, Marianyela; Calderón Fallas, Rafael A. (Universidad Nacional, Costa Rica, 2020-07-01)
      El primer reporte sobre la presencia del Pequeño Escarabajo de la Colmena (PEC), Aethina tumida, en Costa Rica, se realizó el 25 de agosto 2015, en La Cruz, Guanacaste; lo cual aumenta el riesgo de dispersión a otras zonas ...

    • Epidemiology of bovine brucellosis in Costa Rica: Lessons learned from failures in the control of the disease 

      Hernández-Mora, Gabriela; Ruiz-Villalobos, Nazareth; Bonilla-Montoya, Roberto; Romero-Zúñiga, Juan José; Jiménez-Arias, Julio; González-Barrientos, Rocio; BARQUERO-CALVO, ELIAS; Chacón-Díaz, Carlos; Rojas, Norman; Chaves-Olarte, Esteban; Guzman-Verri, Caterina; Moreno, Edgardo (PLOS ONE, 2017-08-10)
      Brucellosis, caused by Brucella abortus is a major disease of cattle and a zoonosis. In order to estimate the bovine brucellosis prevalence in Costa Rica (CR), a total 765 herds (13078 bovines) from six regions of CR ...

    • Human neutrophils are resistant to Clostridioides difficile toxin B 

      Chaves-Cordero, Catalina; Quesada-Gómez, Carlos; Chaves-Olarte, Esteban; BARQUERO-CALVO, ELIAS (Elsevier, 2022-03-21)
      Objective: The main objective of this study was to evaluate the glucosyltransferase activity of C. difficile TcdB on the activity of human PMNs. Methods: To better understand the interaction between PMNs and TcdB, PMNs ...

    • In vivo proteolytic degradation of the Escherichia coli acyltransferase HlyC 

      Guzman-Verri, Caterina; Chaves-Olarte, Esteban; García, Fernando; Arvidson, Staffan; Moreno, Edgardo (The American Society for Biochemistry and Molecular Biology, 2001-05-18)
      Escherichia coli hemolysin (HlyA) is the prototype toxin of a major family of exoproteins produced by Gram-negative bacteria known as “repeats in toxins.” Only fatty acid-acylated HlyA molecules at residues Lys564 and ...

    • Intracellular adaptation of Brucella abortus 

      Lamontagne, Julie; Forest, Anik; Marazzo, Elena; François, Denis; Butler, Heather; Michaud, Jean-François; Boucher, Lyne; Pedro, Ida; Villeneuve, Annie; Sitnikov, Dmitri; Trudel, Sylvie; Nassif, Najib; Boudjelt, Djamila; Tomaki, Fadi; Chaves-Olarte, Esteban; Guzman-Verri, Caterina; Brunet, Sylvain; Côté-Martin, Alexandra; Hunter, Joanna; Moreno, Edgardo; Paramithiotis, Eustache (Universidad Nacional, Costa Rica, 2009-03)
      Macrophages were infected with virulent B. abortus strain 2308 or attenuated strain 19. Intracellular bacteria were recovered at different times after infection and their proteomes compared. The virulent strain initially ...

    • Isolation and identification of Arcobacter species from Costa Rican poultry production and retail sources 

      Zumbado, Leana; Barboza, Karol; Angulo, Irina; Redondo-Solano, Mauricio; Castro, Eduardo; Arias, María Laura (Journal of food protection, 2017-04-03)
      Arcobacter is a gram-negative rod recognized as a potential food- and waterborne pathogen; nevertheless, little is known about the effects of this pathogen on human and animal health. Although Arcobacter species are commonly ...

    • Isolierung von Coronaviren in der Zellkultur aus Nasentupferproben atemwegskranker Kalber in der Bundesrepublik Deutschland 

      Jiménez, Carlos; Herbst, W; Müller, J.M; SCHLIESSER, TH (Paul Parey Scientific Publishers, 1989)
      Isolation in tissue culture of coronavirus from respiratory diseased calves in the FRG Coronavirus was isolated in HRT-IS tissue culture from nasal swabs of 4 from 15 calves showing respiratory symptoms. The strains ...

    • Long-term in vivo performance of low-temperature 3D-printed bioceramics in an equine model 

      Vindas Bolaños, Rafael; Castilho, Miguel; de Grauw, Janny; Cokelaere, Stefan M.; Plomp, Saskia; Groll, Jürgen; van Weeren, René; Gbureck, Uwe; Malda, Jos (American Chemical Society, 2020-01-31)
      Bone has great self-healing capacity, but above a certain critical size, bone defects will not heal spontaneously, requiring intervention to achieve full healing. Among the synthetic calcium phosphate (CaP) bone replacement ...

    • Molecular characterization of Brucella ovis in Argentina 

      Alvarez, Lucía P.; Ruiz-Villalobos, Nazaret; Suárez-Esquivel, Marcela; Thomson, Nicholas; Marcellino, Romanela; Viquez Ruiz, Eunice; Robles, Carlos A.; Guzman-Verri, Caterina (Elsevier B.V., 2020-04-22)
      La brucelosis en los carneros es causada por Brucella ovis o Brucella melitensis y se considera una de las enfermedades infecciosas más importantes de los machos en los países donde se crían ovejas. Caracterización molecular ...

    • Nanofracturing: a new technique for bone marrow stimulation in equine cartilage repair 

      Cokelaere, Stefan M.; Vindas Bolaños, Rafael; Both, Sanne K.; Vullers, Mariëlle; Korthagen, Nicoline; van Weeren, René; de Grauw, Janny (Pferdeheilkunde, 2020-02-10)
      Microfracture is the current standard in treatment of focal full-thickness cartilage lesions in horses, but clinical outcome may vary. Nanofracture is a novel technique that uses a commercially developed device to yield ...

    • Neurobrucellosis in stranded dolphins, Costa Rica 

      Hernández-Mora, Gabriela; González-Barrientos, Rocio; Morales, Juan Alberto; Chaves-Olarte, Esteban; Guzman-Verri, Caterina; BARQUERO-CALVO, ELIAS; De-Miguel, María-Jesús; Marín, Clara-María; Blasco, Jose-María; Moreno, Edgardo (Universidad Nacional, Costa Rica, 2008-09)
      Ten striped dolphins, Stenella coeruleoalba, stranded along the Costa Rican Pacifi c coast, had meningoencephalitis and antibodies against Brucella spp. Brucella ceti was isolated from cerebrospinal fl uid of 6 dolphins ...

    • Orthotopic bone regeneration within 3D printed bioceramic scaffolds with region-dependent porosity gradients in an equine model 

      Vindas Bolaños, Rafael; Diloksumpan, Paweena; Cokelaere, Stefan; Pouran, Behdad; de Grauw, Janny; van Rijen, Mattie; van Weeren, René; Levato, Riccardo; Malda, Jos (WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2020-03-03)
      The clinical translation of three-dimensionally printed bioceramic scaffolds with tailored architectures holds great promise toward the regeneration of bone to heal critical-size defects. Herein, the long-term in vivo ...

    • Pathology of striped dolphins (Stenella coeruleoalba) infected with Brucella ceti 

      González-Barrientos, Rocio; Morales, Juan Alberto; Hernández-Mora, Gabriela; BARQUERO-CALVO, ELIAS; Guzman-Verri, Caterina; Chaves-Olarte, Esteban; Moreno, Edgardo (Elsevier Ltd, 2009-10-14)
      Seventeen striped dolphins (Stenella coeruleoalba) displaying swimming disorders compatible with neurological syndromes were investigated for Brucella infection. Sixteen dolphins had meningoencephalomyelitis. Serum antibody ...