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Recent Submissions

  • GTPases of the Rho Subfamily are Required for Brucella abortus internalization in nonprofessional phagocytes 

    Guzman-Verri, Caterina; Chaves-Olarte, Esteban; von Eichel-Streiber, Christoph (The American Society for Biochemistry and Molecular Biology, Inc., 2001-11-30)
    Members of the genus Brucella are intracellular -Proteobacteria responsible for brucellosis, a chronic disease of humans and animals. Little is known about Brucella virulence mechanisms, but the abilities of these ...
  • Barreras que impiden la práctica de actividad física en personas adultas mayores basado en su estado de salud revisión sistemática 

    Cortéz Gómez, Brynel de los Ángeles (Universidad Nacional, Costa Rica., 2020)
    Revisa sistemáticamente la literatura de estudios cualitativos, centrándose en la identificación de barreras que los adultos mayores perciben para involucrarse en actividad física. Metodología: la revisión abarcó las bases ...
  • Efecto del consumo de nitratos derivados del jugo de remolacha sobre la resistencia a la fatiga durante sprint repetidos una revisión sistemática 

    Montoya Rodríguez, Jacqueline Andrea (Universidad Nacional, Costa Rica, 2020)
    Explora el conocimiento reportado hasta la actualidad sobre el efecto del consumo de nitratos derivados del jugo de remolacha para obtener una mejora en la resistencia a la fatiga durante la ejecución de sprints repetidos. ...
  • Activation of Rho and Rab GTPases dissociates Brucella abortus internalization from intracellular trafficking 

    Chaves-Olarte, Esteban; Guzman-Verri, Caterina; Méresse, Stephane; Desjardins, Michel; Pizarro-Cerdá, Javier; Badilla, Jenny; Gorvel, Jean-Pierre; Moreno, Edgardo (Blackwell Science, 2002-10-04)
    Brucella abortus is an intracellular pathogen that relies on unconventional virulence factors to infect hosts. In non-professional phagocytes, Rho GTPasesactivation by the Escherichia coli cytotoxic necrotiz ing factor ...
  • Regulation of Brucella virulence by the two-component system BvrR/BvrS 

    López-Goñi, Ignacio; Guzman-Verri, Caterina; Manterola, Lorea; Sola-Landa, Alberto; Moriyon, Ignacio; Moreno, Edgardo (Elsevier B.V., 2002-12-20)
    The Brucella BvrR/BvrS two-component regulatory system is highly similar to the regulatory and sensory proteins of Sinorhizobium and Agrobacterium necessary for endosymbiosis and pathogenicity in plants, and very similar ...
  • R-Ras Glucosylation and transient RhoA activation determine the cytopathic effect produced by Toxin B variants from Toxin A-negative strains of clostridium difficile 

    Chaves-Olarte, Esteban; Freer, Enrique; Parra, Andrea; Guzman-Verri, Caterina; Moreno, Edgardo; Thelestam, Mónica (American Society for Biochemistry and Molecular Biology, 2003-03-07)
    Clostridium difficile induces antibiotic-associated diarrhea through the production of toxin A and toxin B; the former toxin has been assumed to be responsible for the symptoms of the disease. Several toxin A-negative ...
  • Programa físico recreativo para fomentar la comunicación e interacción entre dos poblaciones : adolescente y adulto mayor, ambas del sexo femenino del distrito de Hatillo. 

    Acuña Solano, Saúl; Madrigal Vindas, Christian; Rosales Chacón, Sergio (Universidad Nacional, Costa Rica, 2005)
    Establece un programa físico recreativo para las poblaciones adulto mayor y adolescentes del sexo femenino, con el cual ambas generaciones puedan interactuar y comunicarse con más eficiencia entre sí. En este estudio ...
  • Cifra de infectados por Covid-19 podría ser mayor 

    Núñez Z., Johnny (Oficina de Comunicación, Universidad Nacional, 2020-10)
    Desde hace siete meses cuando, se registró el primer contagio por coronavirus en Costa Rica, hubo una primera etapa de 90 días con una baja cantidad de casos, pero desde la segunda semana de julio la curva de contagios ...
  • Serological detection of viral infections in captive wild cats from Costa Rica 

    Blanco-Peña, Kinndle; Peña, Roberto; Hernández, Carmen; Jiménez-Soto, Mauricio; Nazario Araya, Luis; Romero-Zúñiga, Juan José; Dolz, Gaby (Veterinary Medicine International, 2011-02-08)
    Serum samples from a total of 44 wildcats, 28 margays (Leopardus wiedii), 10 ocelots (Leopardus pardalis), four jaguaroundis (Herpailurus yaguaroundi), one oncilla (Leopardus tigrina), and one jaguar (Panthera onca) were ...
  • Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infection 

    BARQUERO-CALVO, ELIAS; Chaves-Olarte, Esteban; Weiss, David; Guzman-Verri, Caterina; Chacón-Díaz, Carlos; Rucavado, Alexandra; Moriyon, Ignacio; Moreno, Edgardo (PLOS ONE, 2007-07-18)
    Background. To unravel the strategy by which Brucella abortus establishes chronic infections, we explored its early interaction with innate immunity. Methodology/Principal Findings. Brucella did not induce proinflammatory ...
  • BvrR/BvrS-controlled outer membrane proteins Omp3a and Omp3b are not essential for Brucella abortus virulence 

    Manterola, Lorea; Guzman-Verri, Caterina; Chaves-Olarte, Esteban; BARQUERO-CALVO, ELIAS; de Miguel, María-Jesús; Moriyon, Ignacio; Grillo, María-Jesús; López-Goñi, Ignacio; Moreno, Edgardo (American Society for Microbiology, 2007-07-30)
    The Brucella abortus two-component regulatory system BvrR/BvrS controls the expression of outer membrane proteins (Omp) Omp3a (Omp25) and Omp3b (Omp22). Disruption of bvrS or bvrR generates avirulent mutants with altered ...
  • Neurobrucellosis in stranded dolphins, Costa Rica 

    Hernández-Mora, Gabriela; González-Barrientos, Rocio; Morales, Juan Alberto; Chaves-Olarte, Esteban; Guzman-Verri, Caterina; BARQUERO-CALVO, ELIAS; De-Miguel, María-Jesús; Marín, Clara-María; Blasco, Jose-María; Moreno, Edgardo (Universidad Nacional, Costa Rica, 2008-09)
    Ten striped dolphins, Stenella coeruleoalba, stranded along the Costa Rican Pacifi c coast, had meningoencephalitis and antibodies against Brucella spp. Brucella ceti was isolated from cerebrospinal fl uid of 6 dolphins ...
  • Intracellular adaptation of Brucella abortus 

    Lamontagne, Julie; Forest, Anik; Marazzo, Elena; François, Denis; Butler, Heather; Michaud, Jean-François; Boucher, Lyne; Pedro, Ida; Villeneuve, Annie; Sitnikov, Dmitri; Trudel, Sylvie; Nassif, Najib; Boudjelt, Djamila; Tomaki, Fadi; Chaves-Olarte, Esteban; Guzman-Verri, Caterina; Brunet, Sylvain; Côté-Martin, Alexandra; Hunter, Joanna; Moreno, Edgardo; Paramithiotis, Eustache (Universidad Nacional, Costa Rica, 2009-03)
    Macrophages were infected with virulent B. abortus strain 2308 or attenuated strain 19. Intracellular bacteria were recovered at different times after infection and their proteomes compared. The virulent strain initially ...
  • Serological diagnosis of brucella infections in odontocetes 

    Hernández-Mora, Gabriela; Manire, Charles A.; González-Barrientos, Rocío; BARQUERO-CALVO, ELIAS; Guzman-Verri, Caterina; Staggs, Lydia; Thompson, Rachel; Chaves-Olarte, Esteban; Moreno, Edgardo (American Society for Microbiology, 2009-04-15)
    Brucella ceti causes disease in Odontoceti. The absence of control serum collections and the diversity of cetaceans have hampered the standardization of serological tests for the diagnosis of cetacean brucellosis. Without ...
  • The role of neutrophils in Brucellosis 

    BARQUERO-CALVO, ELIAS; Moreno, Edgardo (American Society for Microbiology, 2020-10-14)
    Brucellosis is a bacterial disease of domestic animals and humans. The pathogenic ability of Brucella organisms relies on their stealthy strategy and their capacity to replicate within host cells and to induce long-lasting ...
  • The differential interaction of brucella and ochrobactrum with innate immunity reveals traits related to the evolution of stealthy pathogens 

    BARQUERO-CALVO, ELIAS; Conde-Álvarez, Raquel; Chacón-Díaz, Carlos; Quesada-Lobo, LucÍa; Martirosyan, Anna; Guzman-Verri, Caterina; Iriarte, Maite; Manček Keber, Mateja; Jerala, Roman; Gorvel, Jean-Pierre; Moriyon, Ignacio; Moreno, Edgardo; Chaves-Olarte, Esteban (PLOS ONE, 2009-06-16)
    Background: During evolution, innate immunity has been tuned to recognize pathogen-associated molecular patterns. However, some a-Proteobacteria are stealthy intracellular pathogens not readily detected by this system. ...
  • Pathology of striped dolphins (Stenella coeruleoalba) infected with Brucella ceti 

    González-Barrientos, Rocio; Morales, Juan Alberto; Hernández-Mora, Gabriela; BARQUERO-CALVO, ELIAS; Guzman-Verri, Caterina; Chaves-Olarte, Esteban; Moreno, Edgardo (Elsevier Ltd, 2009-10-14)
    Seventeen striped dolphins (Stenella coeruleoalba) displaying swimming disorders compatible with neurological syndromes were investigated for Brucella infection. Sixteen dolphins had meningoencephalomyelitis. Serum antibody ...
  • The two-component system BvrR/BvrS regulates the expression of the Type IV secretion system VirB in Brucella abortus 

    Martínez-Núñez, Carola; Altamirano-Silva, Pamela; Alvarado-Guillén, Francisco; Moreno, Edgardo; Guzman-Verri, Caterina; Chaves-Olarte, Esteban (American Society for Microbiology, 2010-11)
    The pathogenesis of Brucella is related to the ability to multiply intracellularly, an event controlled by the two-component system BvrR/BvrS (TCS BvrRS) and the type IV secretion machinery VirB (T4SS VirB). We have ...
  • The use of green fluorescent protein as a marker for Brucella vaccines 

    Chacón-Díaz, Carlos; Muñoz, Melissa; BARQUERO-CALVO, ELIAS; Guzman-Verri, Caterina; Chaves-Olarte, Esteban; Grilló, María-Jesús; Moreno, Edgardo (Elsevier, 2010-11-04)
    La brucelosis es una importante enfermedad de los animales de producción y de la fauna silvestre y una zoonosis mundial. El uso de vacunas eficaces y las correspondientes pruebas de diagnóstico que permiten diferenciar los ...
  • Human Brucella melitensis infections in southern Vietnam 

    Campbell, J.I.; Lan, Nguyen Thi; Phuong, P.M.; Chau, L.B.; Pham, Trung Duc; Guzman-Verri, Caterina; Ruiz-Villalobos, Nazareth; Minh, T.P.T.; Muñoz Bruque, Álvaro; Moreno, Edgardo; Thwaites, G.E.; Rabaa, M.A.; Chau, N.V.V.; Bake, S. (European Society of Clinical Microbiology and Infectious Diseases, 2017-06-29)
    Brucellosis is a collective term for infections caused by small Gram-negative coccobacilli belonging to genus Brucella. This genus incorporates the well-described animal pathogens Brucella melitensis, Brucella abortus, ...

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