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Brucella neotomae infection in humans, Costa Rica
(Emerging Infectious Diseases, 2017-06)
Several species of Brucella are known to be zoonotic, but B. neotomae infection has been thought to be limited to wood rats. In 2008 and 2011, however, B. neotomae was isolated from cerebrospinal fluid of 2 men with ...
Brucellosis caused by the wood rat pathogen Brucella Neotomae: two case reports
(Journal of Medical Case Reports, 2017-12-19)
Background: Brucellosis is a chronic bacterial disease caused by members of the genus Brucella. Among the classical species stands Brucella neotomae, until now, a pathogen limited to wood rats. However, we have identified ...
Brucella canis is an intracellular pathogen that induces a lower proinflammatory response than smooth zoonotic counterparts
(Infection and Immunity, 2015-09-29)
Canine brucellosis caused by Brucella canis is a disease of dogs and a zoonotic risk. B. canis harbors most of the virulence determinants defined for the genus, but its pathogenic strategy remains unclear since it has not ...
The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition
(PLoS Pathogens, 2012-05-10)
Innate immunity recognizes bacterial molecules bearing pathogen-associated molecular patterns to launch inflammatory responses leading to the activation of adaptive immunity. However, the lipopolysaccharide (LPS) of the ...
A Sinorhizobium meliloti and Agrobacterium tumefaciens ExoR ortholog is not crucial for Brucella abortus virulence
(PLOS ONE, 2021-08-13)
Brucella is a facultative extracellular-intracellular pathogen that belongs to the Alphaproteo-
bacteria class. Precise sensing of environmental changes and a proper response mediated
by a gene expression regulatory ...
Phenotypes controlled by the Brucella abortus two component system BvrR/BvrS are differentially impacted by BvrR phosphorylation
(Frontiers Media S.A, 2023-05-10)
Brucella abortus is a zoonotic pathogen whose virulence depends on its ability to survive intracellularly at the endoplasmic reticulum derived compartment. The two-component system BvrR/BvrS (BvrRS) is essential for ...