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Platelet depletion does not alter the course of Brucella abortus infection in vivo
(Elsevier, 2022-02-23)
Brucellosis is a bacterial disease of animals and a zoonotic infection. Thrombocytopenia is a common outcome in
long-lasting brucellosis in humans. Likewise, ex vivo experiments have shown that platelets may play a role ...
Determination of streptomycin and doxycycline using LC/MS towards an effective treatment against an experimental Brucella abortus infection in mice
(Elsevier B.V, 2022-02-25)
Herein we described a versatile liquid chromatographic method for detection and quantification of the total
levels of two antimicrobials [i.e., streptomycin (STM) and doxycycline (DOX)], in mice plasma and selected
tissues, ...
Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes
(American Society for Microbiology, 1988-09-01)
Brucella abortus is an intracellular pathogen that replicates within a membrane-bounded compartment. In
this study, we have examined the intracellular pathway of the virulent B. abortus strain 2308 (S2308) and the
attenuated ...
Brucella-Salmonella lipopolysaccharide chimeras are less permeable to hydrophobic probes and more sensitive to cationic peptides and EDTA than are their native Brucella sp. counterparts
(American Society for Microbiology, 1996-08-12)
A rough (R) Brucella abortus 45/20 mutant was more sensitive to the bactericidal activity of polymyxin B and lactoferricin B than was its smooth (S) counterpart but considerably more resistant than Salmonella montevideo. ...
Characterization of Brucella abortus and Brucella melitensis native haptens as outer membrane O-type polysaccharides independent from the smooth lipopolysaccharide
(American Society for Microbiology, 1996)
Brucella native haptens (NHs) extracted with hot water from smooth (S)- type B. abortus and B. melitensis were purified to high levels of serological activity and compared with the polysaccharide obtained by acid hydrolysis ...
Characterization of Brucella abortus lipopolysaccharide macrodomains as mega rafts
(Blackwell Science, 2005-09-28)
The lipopolysaccharides (LPS) of intracellular Proteobacteria such as Brucella, Chlamydia, Legionella and Rickettsia, have properties distinct from enterobacterial LPSs. These properties include deficient LPS induction of ...
In search of a bacterial spedes definition
(Universidad de Costa Rica., 1997)
The bacterial species concept was examined within the framework of plant and animal associated a-2 proteobacteria, taking into consideration the phylogenetic, taxonomic and biological approaches as well as the microbiologists' ...
MyD88, but not Toll-Like receptors 4 and 2, Is required for efficient clearance of Brucella abortus
(American Society for Microbiology, 2005-08)
It is not clear how the host initially recognizes and responds to infection by gram-negative pathogenic
Brucella spp. It was previously shown (D. S. Weiss, B. Raupach, K. Takeda, S. Akira, and A. Zychlinsky, J.
Immunol. ...
The regulon of Brucella abortus two- component system BvrR/BvrS reveals the coordination of metabolic pathways required for intracellular life
(PLOS ONE, 2022-09-21)
Brucella abortus is a facultative intracellular pathogen causing a severe zoonotic disease
worldwide. The two-component regulatory system (TCS) BvrR/BvrS of B. abortus is con-
served in members of the Alphaproteobacteria ...
Persistence of Brucella abortus lineages revealed by genomic characterization and phylodynamic analysis
(PLOS Neglected Tropical Diseases, 2020-04-14)
Brucellosis, caused by Brucella abortus, is a major disease of cattle and humans worldwide distributed. Eradication and control of the disease has been difficult in Central and South America, Central Asia, the Mediterranean ...