Synthesis of Dihydroindolo[2,3-c]carbazole as Potential Telomerase Inhibitor

Abstract

The dictyodendrins A-E were the first marine natural products that show inhibition of telomerase. A versatile and convergent route was described for the synthesis of derivatives of these pyrrolo[2,3-c]carbazole alkaloids as potential inhibitors of telomerase, by cyclotrimerization [2 + 2 + 2] of ruthenium-catalyzed diynamides diarylacetylenes. © 2015 HeteroCorporation.Las dictyodendrins A – E fueron los primeros productos naturales marinos que mostraron inhibición de la telomerasa. Se describió una ruta versátil y convergente para la síntesis de derivados de estos alcaloides de pirrolo [2,3 ‐ c] carbazol como inhibidores potenciales de la telomerasa, por ciclotrimerización [2 + 2 + 2] de diinamidales y dialacetilenos catalizados por rutenio.