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Persistence of Brucella abortus in the bone marrow of infected mice
(Journal of Immunology Research, 2018-12-03)
Brucellosis is a zoonotic bacterial infection that may persist for long periods causing relapses in antibiotic-treated patients. The ability of Brucella to develop chronic infections is linked to their capacity to invade ...
What have we learned from brucellosis in the mouse model?
(Veterinary Research, 2012)
Brucellosis is a zoonosis caused by Brucella species. Brucellosis research in natural hosts is often precluded by
practical, economical and ethical reasons and mice are widely used. However, mice are not natural Brucella ...
The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition
(PLoS Pathogens, 2012-05-10)
Innate immunity recognizes bacterial molecules bearing pathogen-associated molecular patterns to launch inflammatory responses leading to the activation of adaptive immunity. However, the lipopolysaccharide (LPS) of the ...
A Sinorhizobium meliloti and Agrobacterium tumefaciens ExoR ortholog is not crucial for Brucella abortus virulence
(PLOS ONE, 2021-08-13)
Brucella is a facultative extracellular-intracellular pathogen that belongs to the Alphaproteo-
bacteria class. Precise sensing of environmental changes and a proper response mediated
by a gene expression regulatory ...
The regulon of Brucella abortus two- component system BvrR/BvrS reveals the coordination of metabolic pathways required for intracellular life
(PLOS ONE, 2022-09-21)
Brucella abortus is a facultative intracellular pathogen causing a severe zoonotic disease
worldwide. The two-component regulatory system (TCS) BvrR/BvrS of B. abortus is con-
served in members of the Alphaproteobacteria ...
A bvrR/bvrS Non-Polar Brucella abortus Mutant Confirms the Role of the Two-Component System BvrR/BvrS in Virulence and Membrane Integrity
(MDPI, 2023-08-05)
Brucella abortus is a bacterial pathogen causing bovine brucellosis worldwide. This facultative extracellular–intracellular pathogen can be transmitted to humans, leading to a zoonotic disease.
The disease remains a public ...
Phenotypes controlled by the Brucella abortus two component system BvrR/BvrS are differentially impacted by BvrR phosphorylation
(Frontiers Media S.A, 2023-05-10)
Brucella abortus is a zoonotic pathogen whose virulence depends on its ability to survive intracellularly at the endoplasmic reticulum derived compartment. The two-component system BvrR/BvrS (BvrRS) is essential for ...
The Brucella abortus two-component system response regulator BvrR binds to three DNA regulatory boxes in the upstream region of omp25
(Frontiers Media S.A, 2023-09-14)
Brucella abortus is a facultative extracellular-intracellular bacterial zoonotic pathogen worldwide. It is also a major cause of abortion in bovines, generating economic losses. The two-component regulatory system BvrR/BvrS ...