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Brucella abortus induces the premature death of human neutrophils through the action of Its lipopolysaccharide
(PLoS Pathogens, 2015-05-06)
Most bacterial infections induce the activation of polymorphonuclear neutrophils (PMNs), enhance their microbicidal function, and promote the survival of these leukocytes for protracted periods of time. Brucella abortus ...
Persistence of Brucella abortus in the bone marrow of infected mice
(Journal of Immunology Research, 2018-12-03)
Brucellosis is a zoonotic bacterial infection that may persist for long periods causing relapses in antibiotic-treated patients. The ability of Brucella to develop chronic infections is linked to their capacity to invade ...
What have we learned from brucellosis in the mouse model?
(Veterinary Research, 2012)
Brucellosis is a zoonosis caused by Brucella species. Brucellosis research in natural hosts is often precluded by
practical, economical and ethical reasons and mice are widely used. However, mice are not natural Brucella ...
The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition
(PLoS Pathogens, 2012-05-10)
Innate immunity recognizes bacterial molecules bearing pathogen-associated molecular patterns to launch inflammatory responses leading to the activation of adaptive immunity. However, the lipopolysaccharide (LPS) of the ...
Brucella β 1,2 cyclic glucan is an activator of human and mouse dendritic cells
(PLoS Pathogens, 2012-11-15)
Bacterial cyclic glucans are glucose polymers that concentrate within the periplasm of alpha-proteobacteria. These molecules are necessary to maintain the homeostasis of the cell envelope by contributing to the osmolarity ...
Neutrophils exert a suppressive effect on Th1 responses to intracellular pathogen Brucella abortus
(PLoS Pathogens, 2013-02-14)
Polymorphonuclear neutrophils (PMNs) are the first line of defense against microbial pathogens. In addition to their role in innate immunity, PMNs may also regulate events related to adaptive immunity. To investigate the ...
The differential interaction of brucella and ochrobactrum with innate immunity reveals traits related to the evolution of stealthy pathogens
(PLOS ONE, 2009-06-16)
Background: During evolution, innate immunity has been tuned to recognize pathogen-associated molecular patterns. However, some a-Proteobacteria are stealthy intracellular pathogens not readily detected by this system. ...
Activation of Rho and Rab GTPases dissociates Brucella abortus internalization from intracellular trafficking
(Blackwell Science, 2002-10-04)
Brucella abortus is an intracellular pathogen that relies on unconventional virulence factors to infect hosts. In non-professional phagocytes, Rho GTPasesactivation by the Escherichia coli cytotoxic necrotiz ing factor ...
GTPases of the Rho subfamily are required for Brucella abortus internalization in nonprofessional phagocytes
(The American Society for Biochemistry and Molecular Biology, Inc., 2001-11-30)
Members of the genus Brucella are intracellular -Proteobacteria
responsible for brucellosis, a chronic disease
of humans and animals. Little is known about Brucella
virulence mechanisms, but the abilities of these ...
Brucella abortus ornithine lipids are dispensable outer membrane components devoid of a marked pathogen-associated molecular pattern
(PLoS One, 2011-01-07)
The brucellae are a-Proteobacteria facultative intracellular parasites that cause an important zoonosis. These bacteria escape early detection by innate immunity, an ability associated to the absence of marked pathogen-associated ...