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Artículos científicos

URI permanente para esta colecciónhttp://10.0.96.45:4000/handle/11056/14837

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Examinando Artículos científicos por Materia "ANXIETY"

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    Ítem
    Clinical observations and safety profile of oral herbal products, souroubea and platanus spp: a pilot-toxicology study in dogs
    (Universidad Nacional, Costa Rica, 2014-04-07) Villalobos, Pedro; Baker, John; Sánchez Vindas, Pablo; Durst, Tony; Masic, Aleksandar; Arnasont, John
    This pilot-study evaluated the toxicity and safety profi le of two herbal products Souroubea spp Botanical Blend (SSBB) and Platanus Tree Bark (PTB) after oral administration to dogs at elevated doses for 28 days. SSBB and PTB botanicals are the major active ingredients of Sin Susto, a novel natural product for the treatment of anxiety in dogs. Three healthy female dogs were administered elevated doses of either SSBB, PTB or a placebo and then monitored for the occurrence of any systemic and local adverse events. Data from this pilot-study revealed that SSBB and PTB had no untoward effects on the health of dogs and were deemed safe which enabled the design and execution of a larger controlled target safety and toxicology study for Sin Susto.
  • Miniatura
    Ítem
    Ethnopharmacology of Souroubea sympetala and Souroubea gilgii (Marcgraviaceae) and identification of betulinic acid as an anxiolytic principle
    (Elsevier, 2015-05) Puniani, Eva; Cayer, Christian; Kent, Pamela; Mullally, Martha; Sánchez-Vindas, Pablo; Poveda Álvarez, Luis; Cal, Victor; Merali, Zul; Arnason, John; Durst, Tony
    The neotropical lianas Souroubea gilgii and Souroubea sympetala (Marcgraviaceae) were chosen for study as part of a phytochemical discovery strategy focusing on rare plant families in Central America. In participatory research, Q’eqchi’ healers in Belize reported the use of these plants to reverse psychological symptoms inflicted by witchcraft. Extracts of two Souroubea species showed significant anti-anxiety activity in the elevated plus maze, a standardized test paradigm. Bioassay guided isolation led to the active principle, the pentacyclic triterpene, betulinic acid, which had activity in the elevated plus maze at 0.5 mg/kg. Other phytochemicals isolated included α- and β-amyrin, 2-hydroxyursolic acid, taraxenyl trans-4-hydroxy-cinnamate, naringenin, methyl ursolate, eriodytiol, methyl 2-α-hydroxyursolate, methyl 2-α-hydroxymaslinate, methyl betulinate, and condrilla sterol.