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Inhibition of human pathogenic fungi by ethnobotanically selected plant extracts
(Deutschsprachige Mykologische Gesellschaft, 2003-02-14) Ficker, Christine E.; Arnason, J. T.; Sanchez Vindas, Pablo; Álvarez, L. P.; akpagana, koffi; Gbéassor, M.; De Souza, C.; Smith, M. L.
In this study, 36 extracts derived from 29 plant species selected using an ethnobotanical approach were tested for antifungal activity against a taxonomically diverse group of 13 human pathogenic fungi. We compared the inhibitory characteristics of these plant extracts with those of the commonly used antifungals, amphotericin B and ketoconazole, and the plant-derived antifungal, berberine. Several plant extracts, notably those from Zingiber officinale (ginger) and Juglans cinerea (butternut), had pronounced antifungal activity against a wide variety of fungi, including strains that were highly resistant to amphotericin B and ketoconazole. Further exploration of Z. officinale as an antifungal is warranted as this species is generally regarded as safe for human consumption.