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R-Ras Glucosylation and Transient RhoA Activation Determine the Cytopathic Effect Produced by Toxin B Variants from Toxin A-negative Strains of Clostridium difficile
(Universidad Nacional, Costa Rica, 2003-03)
Clostridium difficile induces antibiotic-associated di-arrhea through the production of toxin A and toxin B;the former toxin has been assumed to be responsible forthe symptoms of the disease. Several toxin ...
Vesicular stomatitis virus glycoprotein is a determinant of pathogenesis in swine, a natural host
(American Society for Microbiology., 2003-07)
There are two major serotypes of vesicular stomatitis virus (VSV), Indiana (VSIV) and New Jersey (VSNJV).We recovered recombinant VSIVs from engineered cDNAs that contained either (i) one copy of the VSIV G gene(VSIV-GI); ...
The effect of the dam–calf relationship on serostatus to Neospora caninum on 20 Costa Rican dairy farms
(Universidad Nacional, Costa Rica, 2003-03-31)
An epidemiological study was conduced on 20 dairy herds previously diagnosed as seropositive
for Neospora caninum. The number of females per farm varies from 41 to 296. All females present
on the farms were bled once in ...
Pulmonary sarcocystosis in a puppy with canine distemper in Costa Rica
(Universidad Nacional, Costa Rica, 2003-05-01)
Canine distemper and pulmonary sarcocystosis were diagnosed in a 10-week-old Rottweiler with
4-day history of diarrhea, vomiting, and weakness. Microscopic examination of the lung revealed bronchointerstitial pneumonia ...
The differential interaction of brucella and ochrobactrum with innate immunity reveals traits related to the evolution of stealthy pathogens
(PLOS ONE, 2009-06-16)
Background: During evolution, innate immunity has been tuned to recognize pathogen-associated molecular patterns. However, some a-Proteobacteria are stealthy intracellular pathogens not readily detected by this system. ...
Pathology of striped dolphins (Stenella coeruleoalba) infected with Brucella ceti
(Elsevier Ltd, 2009-10-14)
Seventeen striped dolphins (Stenella coeruleoalba) displaying swimming disorders compatible with neurological syndromes were investigated for Brucella infection. Sixteen dolphins had meningoencephalomyelitis. Serum antibody ...
Serological diagnosis of brucella infections in odontocetes
(American Society for Microbiology, 2009-04-15)
Brucella ceti causes disease in Odontoceti. The absence of control serum collections and the diversity of
cetaceans have hampered the standardization of serological tests for the diagnosis of cetacean brucellosis. Without ...
Neurobrucellosis in stranded dolphins, Costa Rica
(Universidad Nacional, Costa Rica, 2008-09)
Ten striped dolphins, Stenella coeruleoalba, stranded along the Costa Rican Pacifi c coast, had meningoencephalitis and antibodies against Brucella spp. Brucella ceti was isolated from cerebrospinal fl uid of 6 dolphins ...
Intracellular adaptation of Brucella abortus
(Universidad Nacional, Costa Rica, 2009-03)
Macrophages were infected with virulent B. abortus strain 2308 or attenuated strain 19. Intracellular bacteria were recovered at different times after infection and their proteomes compared. The virulent strain initially ...
Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infection
(PLOS ONE, 2007-07-18)
Background. To unravel the strategy by which Brucella abortus establishes chronic infections, we explored its early interaction with innate immunity. Methodology/Principal Findings. Brucella did not induce proinflammatory ...