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Now showing items 1418-1437 of 13228

    • Brucella abortus ornithine lipids are dispensable outer membrane components devoid of a marked pathogen-associated molecular pattern 

      Palacios-Chaves, Leyre; Conde-Álvarez, Raquel; Gil-Ramírez, Yolanda; Zúñiga-Ripa, Amaia; BARQUERO-CALVO, ELIAS; Chacón-Díaz, Carlos; Chaves-Olarte, Esteban; Arce-Gorvel, Vilma; Gorvel, Jean-Pierre; Moreno, Edgardo; de Miguel, María-Jesús; Grilló, María-Jesús; Moriyon, Ignacio; Iriarte, Maite (PLoS One, 2011-01-07)
      The brucellae are a-Proteobacteria facultative intracellular parasites that cause an important zoonosis. These bacteria escape early detection by innate immunity, an ability associated to the absence of marked pathogen-associated ...

    • Brucella abortus S19 GFP-tagged vaccine allows the serological identification of vaccinated cattle 

      Chacón-Díaz, Carlos; Zabalza-Baranguá, Ana; San Román, Beatriz; Blasco, Jose-María; Iriarte, Maite; Salas-Alfaro, Dariana; Hernández-Mora, Gabriela; BARQUERO-CALVO, ELIAS; Guzman-Verri, Caterina; Chaves-Olarte, Esteban; Grillo, María Jesús; Moreno, Edgardo (PLOS ONE, 2021-11-22)
      Bovine brucellosis induces abortion in cows, produces important economic losses, and causes a widely distributed zoonosis. Its eradication was achieved in several countries after sustained vaccination with the live ...

    • Brucella abortus senses the intracellular environment through the BvrR/Bvrs two-component system, which allows B. abortus to adapt to its replicative nich 

      Altamirano-Silva, Pamela; Meza-Torres, Jazmín; Castillo-Zeledón, Amanda; Ruiz-Villalobos, Nazareth; Zúñiga Pereira, Ana Mariel; Chacón-Díaz, Carlos; Moreno, Edgardo; Guzman-Verri, Caterina; Chaves-Olarte, Esteban (American Society for Microbiology., 2018-01-16)
      Brucella abortus is a facultative extracellular-intracellular pathogen belonging to a group of Alphaproteobacteria that establishes close interactions with animal cells. This bacterium enters host cells in a membrane-bound ...

    • Brucella abortus strain 2308 Wisconsin genome: Importance of the definition of reference strains 

      Castillo-Zeledón, Amanda; Suárez-Esquivel, Marcela; Ruiz-Villalobos, Nazareth; Jiménez-Rojas, César; Roop, R. Martin; Comerci, Diego J.; BARQUERO-CALVO, ELIAS; Chacón-Díaz, Carlos; Caswell, Clayton C.; Baker, Kate; Chaves-Olarte, Esteban; Thomson, Nicholas; Moreno, Edgardo; LETESSON, Jean-Jacques; De Bolle, Xavier; Guzman-Verri, Caterina (Frontiers in Microbiology, 2016-09-29)
      La brucelosis es una enfermedad infecciosa bacteriana que afecta a una amplia gama de mamíferos y una zoonosis desatendida causada por especies del género genéticamente homogéneo Brucella. Como en la mayoría de los estudios ...

    • Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes 

      PIZARRO CERDA, JAVIER; MERESSE, STEPHANE; PARTON, ROBERT; GISOU, VAN DER; SOLA LANDA, ALBERTO; LOPEZ GOÑI, IGNACIO; GORVEL, JEAN PIERRE; Moreno, Edgardo (American Society for Microbiology, 1988-09-01)
      Brucella abortus is an intracellular pathogen that replicates within a membrane-bounded compartment. In this study, we have examined the intracellular pathway of the virulent B. abortus strain 2308 (S2308) and the attenuated ...

    • Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infection 

      BARQUERO-CALVO, ELIAS; Chaves-Olarte, Esteban; Weiss, David; Guzman-Verri, Caterina; Chacón-Díaz, Carlos; Rucavado, Alexandra; Moriyon, Ignacio; Moreno, Edgardo (PLOS ONE, 2007-07-18)
      Background. To unravel the strategy by which Brucella abortus establishes chronic infections, we explored its early interaction with innate immunity. Methodology/Principal Findings. Brucella did not induce proinflammatory ...

    • Brucella canis is an intracellular pathogen that induces a lower proinflammatory response than smooth zoonotic counterparts 

      Guzman-Verri, Caterina; Chacón-Díaz, Carlos; Altamirano-Silva, Pamela; González-Espinoza, Gabriela; Medina, María-Concepción; Alfaro-Alarcón, Alejandro; Bouza-Mora, Laura; Jiménez-Rojas, César; Wong, Melissa; BARQUERO-CALVO, ELIAS; Rojas, Norman; Moreno, Edgardo; Chaves-Olarte, Esteban (Infection and Immunity, 2015-09-29)
      Canine brucellosis caused by Brucella canis is a disease of dogs and a zoonotic risk. B. canis harbors most of the virulence determinants defined for the genus, but its pathogenic strategy remains unclear since it has not ...

    • Brucella ceti and brucellosis in cetaceans 

      Guzman-Verri, Caterina; González-Barrientos, Rocio; Hernández-Mora, Gabriela; Morales, Juan Alberto; BARQUERO-CALVO, ELIAS; Chaves-Olarte, Esteban; Moreno, Edgardo (Frontiers in cellular and infection microbiology, 2012-02-06)
      Since the first case of brucellosis detected in a dolphin aborted fetus, an increasing number of Brucella ceti isolates has been reported in members of the two suborders of cetaceans: Mysticeti and Odontoceti. Serological ...

    • Brucella ceti infection in dolphins from the Western Mediterranean sea 

      Guzman-Verri, Caterina; Isidoro Ayza, Marcos; Ruiz-Villalobos, Nazareth; Pérez, Lola; Muñoz, Pilar M.; Alegre, Fernando; Barberán, Montserrat; Chacón-Díaz, Carlos; Chaves-Olarte, Esteban; Gonzalez-Barrientos, Rocio; Moreno, Edgardo; Blasco, José María; Domingo, Mariano (Frontiers in cellular and infection microbiology, 2012)
      Background: Brucella ceti infections have been increasingly reported in cetaceans. Brucellosis in these animals is associated with meningoencephalitis, abortion, discospondylitis', subcutaneous abscesses, endometritis and ...

    • Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum 

      Celli, Jean; Chastellier, Chantal de; Franchini, Don Marc; Pizarro Cerda, Javier; Gorvel, Jean Pierre; Moreno, Edgardo (The Rockefeller University Press, 2003-01-18)
      The intracellular pathogen Brucella is the causative agent of brucellosis, a worldwide zoonosis that affects mammals, including humans. Essential to Brucella virulence is its ability to survive and replicate inside host ...

    • Brucella evolution and taxonomy 

      Cloeckaertb, Axel; Moriyon, Ignacio; Moreno, Edgardo (Elsevier Science B.V, 2002)
      The genus Brucella contains alpha-Proteobacteria adapted to intracellular life within cells of a variety of mammals. Controversy has arisen concerning Brucella internal taxonomy, and it has been proposed that the DNA–DNA ...

    • Brucella genetic variability in wildlife marine mammals populations relates to host preference and ocean distribution 

      Suárez-Esquivel, Marcela; Baker, Kate; Ruiz-Villalobos, Nazareth; Hernandez-Mora, Gabriela; BARQUERO-CALVO, ELIAS; González-Barrientos, Rocío; Castillo-Zeledón, Amanda; Jiménez-Rojas, César; Chacón-Díaz, Carlos; Cloeckaert, Axel; Chaves-Olarte, Esteban; Thomson, Nicholas; Moreno, Edgardo; Guzman-Verri, Caterina (Oxford University Press on behalf of the Society for Molecular Biology and Evolution, 2017-07-20)
      Intracellular bacterial pathogens probably arose when their ancestor adapted from a free-living environment to an intracellular one, leading to clonal bacteria with smaller genomes and less sources of genetic plasticity. ...

    • Brucella genomics: macro and micro evolution 

      Guzman-Verri, Caterina; Suárez-Esquivel, Marcela; Chaves Olarte, Esteban; Moreno, Edgardo (MDPI AG, 2020-10-20)
      Brucella organisms are responsible for one of the most widespread bacterial zoonoses, named brucellosis. The disease affects several species of animals, including humans. One of the most intriguing aspects of the brucellae ...

    • Brucella melitensis: a nasty bug with hidden credentials for virulence 

      Moreno, Edgardo; Moriyón, Ignacio (The National Academy of Sciences, 2002-01-08)
      On September 23, 1905, a cargo carrying 60 goats from Malta arrived in New York. The herd was kept in quarantine because of several deaths that occurred during the journey. Crewmen, an agent from the U.S. Bureau of Animal ...

    • Brucella neotomae infection in humans, Costa Rica 

      BARQUERO-CALVO, ELIAS; Baker, Kate S.; Amuy, Ernesto; Chaves-Olarte, Esteban; Thomson, Nicholas R.; Moreno, Edgardo; Guzman-Verri, Caterina; Suárez-Esquivel, Marcela; Ruiz-Villalobos, Nazareth; Jiménez-Rojas, César; Chacón-Díaz, Carlos; Víquez-Ruiz, Eunice; Rojas-Campos, Norman; Oviedo-Sánchez, Gerardo (Emerging Infectious Diseases, 2017-06)
      Several species of Brucella are known to be zoonotic, but B. neotomae infection has been thought to be limited to wood rats. In 2008 and 2011, however, B. neotomae was isolated from cerebrospinal fluid of 2 men with ...

    • Brucella sp. sequence‑type 27 associated with abortion in dwarf sperm whale Kogia sima 

      Hernández-Mora, Gabriela; González-Barrientos, Rocío; Víquez‑Ruíz, Eunice; Palacios Alfaro, Jose David; Bettoni‑Rodríguez, Gianmarco; Gendre, Marlène; Vincent, Charline; Roca‑Monge, Karol; Ruiz-Villalobos, Nazareth; Suárez-Esquivel, Marcela; Cordero‑Chavarría, Minor; Chaves-Olarte, Esteban; Thomson, Nicholas R.; BARQUERO-CALVO, ELIAS; Moreno, Edgardo; Guzman-Verri, Caterina (Springer Link, 2021-05-18)
      A dwarf sperm whale Kogia sima stranded alive along the Central Pacifc Coast of Costa Rica. The whale, handled by tourists and local inhabitants, was weak, had buoyancy difculties, and eventually aborted and died, showing ...

    • Brucella spp. en el hato ovino costarricense 

      Barrantes Granados, Osvaldo (Universidad Nacional, Costa Rica, 2015-03-12)
      La brucelosis en ovinos es causada por Brucella melitensis, B. abortus, y B. ovis, provocando principalmente en el caso de las dos primeras especies, problemas en la reproducción de las hembras y en el caso de B. ovis, ...

    • Brucella β 1,2 cyclic glucan is an activator of human and mouse dendritic cells 

      Moreno, Edgardo; Martirosyan, Anna; Pérez-Gutierrez, Camino; Banchereau, Romain; Dutartre, Helene; Lecine, Patrick; Dullaers, Melissa; MELLO, Marielle; salcedo, suzana; Muller, Alexandre; Leserman, Lee; Levy, Yves; Zurawski, Gerard; Zurawski, Sandy; Moriyon, Ignacio; Klechevsky, Eynav; Banchereau, Jacques; Oh, SangKon; Gorvel, Jean-Pierre (PLoS Pathogens, 2012-11-15)
      Bacterial cyclic glucans are glucose polymers that concentrate within the periplasm of alpha-proteobacteria. These molecules are necessary to maintain the homeostasis of the cell envelope by contributing to the osmolarity ...

    • Brucella-Salmonella lipopolysaccharide chimeras are less permeable to hydrophobic probes and more sensitive to cationic peptides and EDTA than are their native Brucella sp. counterparts 

      Freer, Enrique; Moriyón, Ignacio; Pizarro Cerda, Javier; Weintraub, Andrej; Gorvel, Jean Pierre; Moreno, Edgardo (American Society for Microbiology, 1996-08-12)
      A rough (R) Brucella abortus 45/20 mutant was more sensitive to the bactericidal activity of polymyxin B and lactoferricin B than was its smooth (S) counterpart but considerably more resistant than Salmonella montevideo. ...

    • Brucellosis caused by the wood rat pathogen Brucella Neotomae: two case reports 

      Arnuy, Ernesto; Rojas, Norman; Villalobos-Vindas, Juan M.; BARQUERO-CALVO, ELIAS; Chacón-Díaz, Carlos; Chaves-Olarte, Esteban; Guzman-Verri, Caterina; Moreno, Edgardo (Journal of Medical Case Reports, 2017-12-19)
      Background: Brucellosis is a chronic bacterial disease caused by members of the genus Brucella. Among the classical species stands Brucella neotomae, until now, a pathogen limited to wood rats. However, we have identified ...