Browsing by Author "c0d74320-8230-4222-8259-b119c7f0d71d"
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Brucella melitensis: a nasty bug with hidden credentials for virulence
Moreno, Edgardo; Moriyón, Ignacio (The National Academy of Sciences, 2002-01-08)On September 23, 1905, a cargo carrying 60 goats from Malta arrived in New York. The herd was kept in quarantine because of several deaths that occurred during the journey. Crewmen, an agent from the U.S. Bureau of Animal ... -
Computational biology in Costa Rica: the role of a small country in the global context of bioinformatics
Moreno, Edgardo; Lomonte, Bruno; Gutiérrez, José María (PLoS Computational Biology, 2008-03-14)The successful development of high throughput methods for DNA sequencing, transcriptomics, proteomics, and other –omics, has contributed to the emergence of novel possibilities for the examination of complex biological ... -
Depletion of complement enhances the clearance of Brucella abortus in mice
González-Espinoza, Gabriela; BARQUERO-CALVO, ELIAS; Lizano-González, Esteban; Alfaro-Alarcón, Alejandro; Arias-Gómez, Berny; Chaves-Olarte, Esteban; Moreno, Edgardo; Lomonte, Bruno; Chacón-Díaz, Carlos (American Society for Microbiology, 2018-08-06)Brucellosis is a bacterial disease of animals and humans. Brucella abortus barely activates the innate immune system at the onset of infection, and this bacterium is resistant to the microbicidal action of complement. Since ... -
Facing the human and animal Brucellosis conundrums: the forgotten lessons
Moreno, Edgardo; Blasco, José María; Moriyón, Ignacio (MDPI, 2022-04-30)Brucellosis is a major zoonotic disease caused by Brucella species. Historically, the disease received over fifty names until it was recognized as a single entity, illustrating its protean manifesta- tions and intricacies, ... -
Genome evolution within the alpha Proteobacteria: why do some bacteria not possess plasmids and others exhibit more than one diferent chromosome?
Moreno, Edgardo (Elsevier, 1998)Animal intracellular Proteobacteria of the alpha subclass without plasmids and containing one or more chromosomes are phylogenetically entwined with opportunistic, plant-associated, chemoautotrophic and photosynthetic ... -
The regulon of Brucella abortus two- component system BvrR/BvrS reveals the coordination of metabolic pathways required for intracellular life
Rivas-Solano, Olga; Van der Henst, Mathilde; Castillo-Zeledón, Amanda; Suárez Esquivel, Marcela; Muñoz, Lohendy; Capitan-Barrios, Zeuz; Thomson, Nicholas; Chaves-Olarte, Esteban; Moreno, Edgardo; De Bolle, Xavier; Guzmán Verri, Caterina (PLOS ONE, 2022-09-21)Brucella abortus is a facultative intracellular pathogen causing a severe zoonotic disease worldwide. The two-component regulatory system (TCS) BvrR/BvrS of B. abortus is con- served in members of the Alphaproteobacteria ...